What is 7-OH?
7-hydroxymitragynine (7-OH) is a naturally occurring alkaloid found in kratom (Mitragyna speciosa), though only in very small amounts. It is a metabolite of mitragynine and is considerably more potent at certain receptors in the body.
Based on preclinical research and user reports, 7-hydroxymitragynine is associated with strong analgesic effects due to its activity at mu-opioid receptors and is considered many times more potent than morphine by weight. It may produce sedative and relaxing effects and is often reported to help with sleep, severe discomfort, and opioid withdrawal symptoms. Animal studies suggest a different respiratory profile compared to traditional opioids, but it is not risk-free and remains under ongoing scientific investigation.
Key Properties
Mu-Opioid Receptor Agonist
Binds selectively to μ-opioid receptors, producing analgesic effects estimated to be significantly more potent than morphine by weight.
Mitragynine Metabolite
Occurs naturally in Mitragyna speciosa in trace amounts and is also produced in the body as a primary metabolite of mitragynine.
Sedative & Analgesic Profile
Associated with pain relief, relaxation, and sleep support. Commonly reported in the context of opioid withdrawal management.
Ongoing Scientific Investigation
Active subject of preclinical research. Respiratory safety profile appears distinct from classical opioids, though risks remain under study.
